摘要
目的:探讨体温过高对耳蜗电图(ECochG)的影响及其波的起源.方法:体表物理升温法逐步升高豚鼠体温(36～42 ℃),观察系列体温过高时豚鼠BAEP和ECochG波峰潜伏期(PL)和波峰间潜伏期(IPL)及波幅的动态变化.结果:随体温逐步升高(36～42 ℃),BAEP的Ⅰ、Ⅱ、Ⅲ、Ⅳ波PL和Ⅰ-Ⅳ波IPL与ECochG的N1、N2、N3波PL和N1-N3波IPL随体温升高而逐渐缩短,体温越高,缩短越显著;代表脑干中枢传递时间的BAEP的Ⅰ-Ⅳ波IPL的缩短总值明显大于代表外周传导时间的Ⅰ波PL的缩短总值,且源自脑干中枢的Ⅱ、Ⅲ、Ⅳ波的PL的缩短总值明显大于源自听神经的Ⅰ波PL的缩短总值,ECochG的 N1-N3波IPL的缩短总值也明显大于代表外周传导时间的N1波PL的缩短总值,N2、N3波的PL缩短总值也明显大于源自听神经的N1波PL的缩短总值;BAEP的Ⅰ、Ⅱ、Ⅲ波和ECochG的N1、N2、N3波波幅在体温40 ℃或高过40 ℃以后出现显著降低.结论:体温过高对ECochG的显著影响与BAEP相似,ECochG的N2、N3波较源自听神经的N1波有更高位的神经起源.
Aim： To study the effects of hyperthermia on electrocochleogram （ECochG） and its wave origin. Methods： The body temperature of guinea pigs was increased step by step from 36 ℃ to 42 ℃ with their body contacted with a steel box filled with hot water. The changes of the peak latencies （PL）, interpeak latencies （IPL） and wave amplitudes of BAEP and ECochG had been observed as the body temperature increased gradually. Results： The PL of wave Ⅰ , Ⅱ, Ⅲ and Ⅳ and Ⅰ - IV IPL of BAEP shortened significantly more and more as the body temperature was increased step by step from 36 ℃ to 42 ℃, and the total shortened value of Ⅰ - IV IPL representing the central transmission time of brainstem was much greater than that of wave Ⅰ PL representing the peripheral conduction time and the total shortened values of the PL of the wave Ⅱ , Ⅲ and Ⅳ originated from the brainstem centers were much greater than that of wave I originated from the auditory nerve. The PL of wave N1, N2 and N3and N1 - N3 IPL of ECochG also shortened significantly more and more as the body temperature was increased step by step from 36 ℃ to 42 ℃, and the total shortened value of N1 - N3 IPL was much greater than that of wave N1 PL representing the peripheral conduction time and the total shortened values of the PL of wave N2 and N3 were much greater than that of wave N1 originated from the auditory nerve. The amplitudes of wave Ⅰ , Ⅱ and Ⅲ of BAEP and wave N1, N2 and N3 of ECochG decreased significantly as the body temperature was increased to or over 40 ℃. Conclusion： The significant effects of hypeahennia on ECochG are similar to that of BAEP, and the origin of wave N2 and N3 of ECochG is higher than that of wave N1 which is originated from the auditory nerve.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
北大核心
2005年第4期513-517,共5页
Journal of Jinan University(Natural Science & Medicine Edition)
基金
广东省医学科研基金(342640)资助项目
关键词
体温过高
脑干听觉诱发电位
耳蜗电图
波起源
hypetthennia
brainstem auditory evoked potentials
eleetrocochleogram
wave origin
