摘要
近年细胞色素P450(CYP450)及代谢产物环氧-二十碳三烯酸(EETs)在心肌缺血/再灌注损伤中的作用受到重视。该系统有可能通过对氧自由基生成、钙超载、白细胞激活、一氧化氮、ATP敏感性钾通道、丝裂原激活的蛋白激酶等多靶点影响心肌缺血/再灌注损伤的程度,表现为加重还是减轻损伤与机体状态有关。鉴于心肌缺血及再灌注激活CYP450/EETs系统,探讨影响CYP450/EETs作用的因素,尤其是确定其保护作用的特征及信号转导机制,将进一步阐明心肌缺血/再灌注损伤的发病机制,为防治该类疾病提出新的思路。本文仅就CYP450/EETs系统改变与心肌缺血/再灌注损伤关系做一综述。
Interests on the effects of cytochrome P450 （CYP450） monooxygenases and epoxyeicosatrienoic acids （EETs） on myocardial ischemic-reperfusion injury has been increased in recent years. The CYP450/EET system may influence the degree of myocardial ischemic-reperfusion injury through ＂poly-targets＂, such us oxygen free radical, calcium overload, leukocytes adherence, nitric oxide, ATPsensitive K^＋ channels, and mitogen activated protein kinase. The exaggeration or recovery of injury depends on the physical status. Study of factors that affects CYP450/EET, particularly identification of their involvement in cardioprotective signaling and specific roles, will elucidate the mechanisms of myocardial ischemic-reperfusion injury, and find a new way of prevention and treatment. This article will review the relationship between the changes of CYP450/EETs system and myocardial ischemic-reperfusion injury.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2005年第4期539-542,共4页
Acta Academiae Medicinae Sinicae
基金
北京市教育委员会科技发展计划项目(KM200510025009)~~
