摘要
目的研究急性单侧肺不张(AUA)后发生严重低氧血症的机制。方法将6条犬麻醉后,造成急性左侧肺不张,观察其健侧肺不同分钟通气量(MV)以及患侧肺人工气胸后对肺内分流量(Q_S/Q_T)和动脉血氧分压(PaO_2)的影响。结果 AUA后随着健侧肺MV增加,肺内Q_S/Q_T增加(从19%升至29%),PaO_2下降(从9kPa降至8kPa);患侧肺人工气胸后,肺内Q_S/Q_T减少(从29%降至18%),PaO_2回升(从8kPa升至9kPa)。结论 AUA后是否发生严重低氧血症,取决于健侧肺MV的大小,为避免严重低氧血症,健侧肺应保持适当的通气量。
Objective To study the mechanism of severe hypoxemia associated with acute unilateral ateleetasis (AUA). Methods Six dogs with acute left side atelectasis were studied during the period of rest and exercise. The pulmonary shunt and PaO_2 were measured at different levels of ventilation of right lung. Results After the left side atelectasis during resting condition, the right lung could compensate to produce only mild hypoxemia (PaO_2 9kPa). But with furthter increased ventilation by exercise the shunt increased (from 19% to 29%) and led to severe hypoxemia (PaO_2 8kPa). When an artificial pneumothorax was instituted on the left lung, the shunt decreased (from 29% to 18%) and PaO_2 increased (from 8kPa to 9kPa). Conclusions After AUA, whether severe hypoxemia would occur is determined by the volume of ventilation of the normal side lung. The excess increase of ventilation of the normal side lung by any reason may result in severe hypoxemia.
出处
《中华结核和呼吸杂志》
CAS
CSCD
北大核心
1996年第1期22-25,共4页
Chinese Journal of Tuberculosis and Respiratory Diseases
关键词
肺不张
低氧血症
缺氧症
Atelectasis Respiratory function tests Anoxemia
