摘要
[目的]探讨祛风凉血法在治疗慢性特发性血小板减少性紫癜(ITP)中的作用。[方法]将确诊为慢性血热妄行型ITP患者13例给予祛风凉血中药(主要由苍耳子、蝉蜕、防风、荆芥、水牛角、丹皮、仙鹤草、生地、侧柏叶、赤芍、三七末、甘草等组成)治疗,观察治疗前后ITP患者外周血T细胞亚群和自然杀伤细胞(NK细胞)的变化,并与正常对照组进行比较。[结果]治疗前患者外周血T细胞亚群CD3、CD4、CD4/CD8比值(pCD4/PCD8)和NK细胞水平均低于正常对照组,而CD8含量明显增多(P<0.001);经祛风凉血法治疗后,T淋巴细胞CD3、CD4、pCD4/pCD8和NK细胞均有不同程度的上升,而CD8舍量则有所下降,与治疗前相比差异均有显著性意义(P<0.05或P<0.001)。[结论]祛风凉血法治疗慢性血热妄行型ITP的机理之一可能与其调节T淋巴细胞亚群及NK细胞水平有关。
[Objective] To explore the effect of wind-expelling and blood-cooling therapy in treating chronic idiopathic thromboeytopenia purpum （ITP）. [Methods] Thirteen eases of chronic ITP differentiated in TCM as heat-induced blood extravasation （group A） were treated with wind-expelling and blood-cooling therapy. The changes of peripheral Tlymphocyte subsets and natural killer （NK） cells before and after treatment were observed and compared with the normal volunteers （group B）. [Results] Before treatment, peripheral T-lymphocyte subsets of CDs and CD4 levels, CD4/CD8 ratio and NK cells count were lower in group A than those in group B while CD8 level was higher （ P 〈 0.001 ）. After treatment, peripheral T-lymphocyte subsets of CDs and CD4 levels, CD4/CD8 ratio and NK cells count were inereased to different degrees in group A , and CD8 level was decreased as compared with those before treatment （ P 〈 0.05 or P 〈 0.001）. [ Conclusion] One of the therapeutic mechanisms of wind-expelling and blood-cooling therapy in treating chronic ITP differentiated as heat-induced blood extravasation may be related to the regulation of T-lymphocyte subsets and NK cells.
出处
《广州中医药大学学报》
CAS
2005年第5期344-347,共4页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广东省中医药管理局科研课题(编号:103112)
关键词
紫癜
血小板减少性
特发性/中药疗法
祛风
凉血止血
T淋巴细胞亚群/免疫学
NK细胞/免疫学
PURPURA, THROMBOCYTOPENIA, IDIOPATHIC/TCD therapy
DISPELLING WIND
COOLING BLOOD TO STOP BLEEDING
T-LYMPHOCyrIE SUBSETS/immunology
KILEER CELLS, NATURAL/immunology
