摘要
本实验研究了锌孵育后肝豆状核变性患者和杂合子离体培养皮肤成纤维细胞内铜、锌和金属硫蛋白（ＭＴ）代谢的改变，以及经４５．８８μｍｏｌ／Ｌ锌孵育后，患者胞浆内钢含量增高，同时ＭＴ上的钢结合量也增高，但ＭＴ含量无明显变化，根据上述结果，对锌剂治疗本病的作用机理进行了初步讨论。
The copper, zinc and metallothionein (MT)metabolism in cultured skin fibroblalsts of heterozygotCs and patient with Wilson's disease (hepatolenticular degeneration), together with controls after zin cincubation, were studied. It was found that the copper contents in cytosol and MT fractions of patiellts were elevated after zinc incubation, while the MT contellts in thxee groups remained unchanged.According to the results, the mechanism of zing therapy for Wilson's disease' was discussed in this article.
出处
《中国神经精神疾病杂志》
CSCD
北大核心
1996年第1期13-15,共3页
Chinese Journal of Nervous and Mental Diseases
基金
卫生部重点科研基金
关键词
肝豆状核变性
离体培养
锌剂
铜
金属硫蛋白
Wilson's disease Cultured skinfibroblasts Zinc Copper Metallothionein
