摘要
目的:探讨癌胚抗原(CEA)、糖链抗原 (CA199,casbohydrate antigen19-9)和CA242(casbohydrate antigen 242)在大肠癌的临床价值.方法:采用微粒酶免疫法(MEIA)检测30例大肠良性疾病及45例大肠癌患者血清CEA、CA199和CA242的水平.结果:大肠癌患者与大肠良性疾病患者的CEA、CA199和CA242水平比较差异有显著性(P＜0.01～0.05).血清CEA、CA199和CA242的水平随大肠癌病程的进展而逐渐升高;3种肿瘤标志物中以CA242敏感性和特异性最高,分别为60.3%和73.3%,3种肿瘤标志物对诊断的敏感性与大肠癌的分期有关;联合检测可使诊断的敏感性提高至83.6%.结论:血清CEA、CA199和CA242水平测定可应用于大肠癌的诊断和疗效的观察,并可用于监测肿瘤的复发和转移.肿瘤标志物的联合检测有助于大肠癌的早期诊断,并增加诊断的敏感性和特异性.
Objective： To investigate the clinical value of serum CEA. CA199 and CA242 levels in colon cancer. Methods： Serum CEA. CA199 and CA242 levels in 30 patients with benign colon diseases and 45 with colon carcinoma were detected by microne enzyme immunoassay. Results： Levels of CEA, CA199 and CA242 in cancer group were significantly higher than those in benign disease group （P〈0.01-0. 05）, especially in advanced cases. CA242 was the best diagnostic index among them, and its sensitivity and specificity were 60. 3% and 73.3%, respectively. Their sensitivity was related to tumor staging. Sensitivity of 3 markers was 83.6%. Conclusion： The combined assay of CEA, CA19-9 and CA242 was helpful to early diagnosis of colon carcinoma,
出处
《广东医学院学报》
2005年第4期384-385,共2页
Journal of Guangdong Medical College
关键词
大肠癌
微粒酶免疫法
肿瘤标志物
colon carclnoma
microne enzyme immunoassay
tumor marker
