摘要
目的评价雷帕霉素药物涂层支架(CYPHER,Cordis)对冠心病的早期治疗效果。方法2002年12月至2004年10月38例冠心病患者置入CYPHER支架(38枚,药物支架组),随机选择同期38例接受普通、非药物涂层支架治疗(40枚,裸支架组),比较两组支架置入情况及早期临床事件发生率。结果两组间临床资料、冠脉病变的程度和分型差异无统计学意义,两组支架平均长度相似,但药物支架组平均支架直径较裸支架组显著减少。两组手术成功率相似(100%∶99·0%,P>0·05)。平均随访(5·0±3·1)个月,随访率98·7%,药物支架组心绞痛复发率显著低于裸支架组(5·2%∶23·7%,P<0·01)。结论冠心病患者应用雷帕霉素药物涂层支架治疗早期临床效果优于普通标准支架。
Objective To evaluate the short-term efficacy of coronary drug-eluting stem（DES） in patients with coronary artery disease （CAD）. Methods From December 2002 to October 2004, 38 patients with 38 CYPHER coronary stems（DES group）. The short-term follow-up outcomes of these patients were compared with another 38 well-matched cases who received 40 standard uncoated stems（control group） within the same period. Resuits Baseline clinical characteristics were similar between the two groups. Severity and type of the lesions of coronary arteries in the two groups were comparable. Stents deployed in the DES group were smaller, but the length of the stents in both groups were similar. Immediate procedure success rate was similar（ 100 % vs 99.0 % , P 〉 0.05 ）. During mean （5.3 ±3.1 ） months of follow up, the rate of recurrent angina pectoris was significantly lower in the DES group than that in the control group（5.2 % vs 23.7 % , P 〈 0. 01 ）. Conclusion As compared with standard uncoated coronary stem,DES（CYPHER） provides better short-term clinical efficacy.
出处
《中国基层医药》
CAS
2005年第8期959-960,共2页
Chinese Journal of Primary Medicine and Pharmacy
