摘要
目的探讨大蒜素对实验性兔心肌梗死损伤的延迟保护作用。方法采用心肌梗死重量占危险区心肌重量的百分比(IR)和心肌超微结构,作为心肌梗死损伤指标,观察大蒜素(1、0.5mgkg)预处理对24h后实验性兔心肌梗死损伤的保护作用。结果1mgkg剂量大蒜素延迟预处理能显著减少IR比值达30.62%,并明显改善坏死区心肌的超微结构。结论大蒜素在实验性兔心肌梗死模型能够模拟缺血预处理延迟保护作用,具有药物预处理的潜在价值。
Objective To investigate the cardioprotective effects of delayed preconditioning of allitridium on experimental acute myocardial infarction in rabbits. Methods Rabbits were pretreated using allitridum （1 mg/Kg or 0.5 mg/Kg ）. The percentage of the weight at infarction and at risk （I/R）, the myocardial morphological changes were measured 24 h later to determine the protective effects against experimental ischemiaJreperfussion injury. Results It was observed in hearts treated with 1 mg/Kg allitridium that I/R area decreased 30.62% and the ultrastructure was obviously improved than the compared group. Conclusion Allitriuium can mimic the delayed cardioprctection on experimental acute myocardial infarction in rabbits. AUitridium has potential value in treating coronary heart diseases.
出处
《中国比较医学杂志》
CAS
2005年第4期221-223,共3页
Chinese Journal of Comparative Medicine
关键词
大蒜素
延迟预处理
兔
心肌梗死
实验性
Allitridium
Delayed pretreatmnt
Rabbits
Myocardial infarction, experimental
