摘要
目的应用高频超声显像技术观察低剂量长期激素替代疗法(HRT)对绝经后妇女颈动脉粥样硬化的影响。方法对HRT组(使用低剂量HRT 5年及以上的女性)68例与对照组78例,超声测量其颈动脉的内膜-中层厚度(IMT)和斑块情况,同时测定两侧颈内动脉的收缩期峰值血流速度(PSV)、血管阻力指数(RI)。结果(1)平均IMT HRT组为(0.089±0.022)cm,对照组为(0.093±0.029)cm,两组有显著性差异(P<0.01)。(2)动脉硬化斑块发生率HRT组7.7%,对照组12.7%,两组有显著性差异(P<0.05)。动脉硬化斑块多发生在动脉分叉处。(3)软斑块、混合性斑块HRT组明显少于对照组,而硬斑块HRT组明显多于对照组。软斑块HRT组占1.7%,对照组占4.5%;混合性斑块HRT组占3.1%,对照组占6.7%;硬斑块HRT组占2.6%,对照组占1.3%,(P均<0.05)。(4)HRT组斑块厚度小于对照组,血管狭窄的发生率低,两组有显著性差异(P<0.05)。(5)HRT组PSV:(65.61±26.55)cm/s,RI:(0.67±0.08),对照组分别为(64.82±27.22)cm/s及(0.68±0.08),两组无明显差异(P>0.05)。结论低剂量长期HRT对绝经后妇女颈动脉有保护作用。
Objective： To determine the influence of long-term low-dose hormone replacement therapy （HRT） on the carotid atherosclerosis of postmenopausal women by means of ultrasonic imaging. Methods： One hundred and forty-six postmenopausal women were studied. Of which, 68 were HRT- treated women （HRT group） and 78 were their non-treated counterparts （control group）. The intima and the media thickness （IMT）, the carotid atherosclerosis plaque features, the peak systolic velocity （PSV） of blood flow and the resistance indexes （RI） at the internal carotid arteries on both sides of the two groups were measured by ultrasonic examination. Results： The mean IMT was （0.089±0.22） cm in HRT group and （0. 093±0.29） cm in control group, and there was a significant difference between the two groups （P〈0.01）. The generation percentage of plaques in HRT group was 7.7%, while that in control group was 12.7%, and there was also a significant difference （P〈0.05）. The plaques were often located at the bifurcation of the arteries. The generation rates of the soft and mixed plaques in HRT group （1.7% and 3.1 %, respectively） were significantly less than those of control group （4.5% and 6.7%, respectively）, and the generation rate of the hard plaques of HRTgroup （2.6%） was higher than that of control group （1.3%） （P〈0. 05）. The study showed that there is a possibility that HRT has an effect of making the plaques denser and more stable. The plaque thickness of HRT group was smaller than that of control group, the narrowing rate of blood vessel of HRT group was lower than that of control group and there was a significant difference between them （P〈0.05）. The mean PSV and mean RI in HRT group were similar to those in control group （65.61±26.55） cm/s and （0.67±0.08） cm/s vs. （64.82±27.22） cm/s and （0.68±0.08） cm/s, respectively （P〉0.05）. Conclusion： HRT has an effect of protecting the carotid of the postmenopausal women.
出处
《生殖医学杂志》
CAS
2005年第4期193-197,共5页
Journal of Reproductive Medicine
关键词
激素替代治疗
绝经后
颈动脉
动脉粥样硬化
超声
Hormone replacement therapy
Postmenopausal
Carotid
Atherosclerosis
Ultrasonography
