摘要
对四种天然二聚二苯乙烯类化合物ShegansuB(1),GnetuhaininF(1a),MaackinA(2)以及CassigarolE(3)的全合成进行了研究.以3,5-二羟基苯甲酸(4)为起始原料,经六步反应制得异丹叶大黄素(13)和白皮杉醇(14),在HRP/H2O2酶催化氧化体系中,13和14分别进行自身的氧化偶联得到各自的二聚产物.首次完成了1a,(±)-2和(±)-3的全合成,并以较文献报道为高的氧化偶联产率合成了(±)-1.
The total synthesis of four naturally occurring dimeric stilbenes, （±）-shegansu B （1）, gnetuhainin F （1a）, （±）-maackin A （2） and （±）-cassigarol E （3）, were studied. Isorhapontigenin （13） and piceatannol （14） were prepared from 3,5-dihydroxybenzoic acid in six steps. Oxidative coupling of 13 and 14 with HRP/H2O2 gave their respective dimeric compounds. The first total synthesis of la, （±）-2 and （±）-3 was described and the oxidative coupling yield of synthesis of （±）-1 was higher than that in literatures.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2005年第17期1607-1612,F0007,共7页
Acta Chimica Sinica
