摘要
A new Cadmium!-Ciprofloxacin ionic compound, (HCPFX)2CdCl4·3H2O, is synthesized and its crys- tal structure is determined. The crystallography data are as follows, monoclinic, space group P21/c, a=1.01039(6) nm, b=1.39989(9) nm, c=2.82245(18) nm, β=95.765 0(10)°, V=3.972 0(4) nm3, Z=4, Dc=1.627 g·cm-3, F(000)= 1984. R1=0.0540, wR2=0.1503 (I>2σ(I)). In the title compound, four chloride ions are coordinated to the cadmi- um ion forming a slightly distorted tetrahedron. Both Ciprofloxacin and the compound were assayed against gram- positive and gram-negative bacteria by doubling dilutions method, the compound shows the same minimal in- hibitory concentration (MIC) as the Ciprofloxacin against S. Aureus, M. Lutens, E. Coli and P. Aeruginosa bacte- ria. The inhibitory effect of the two compounds on leukemia HL-60 cell line has been measured by using MTT (Methyl-Thiazol-Tetrozolium) assay method. The results indicate that the complex has very strong inhibitory effect on HL-60 cell line. CCDC: 259367.
A new Cadmium（Ⅱ）-Ciprofloxacin ionic compound, （HCPFX）2[CdCl4]·3H2O, is synthesized and its crys- tal structure is determined. The crystallography data are as follows, monoclinic, space group P21/c, a=1.010 39（6） nm, b=1.399 89（9） nm, c=2.82245（18）nm,β=-95.765 0（10）°, V=3.972 0（4） nm^3, Z=-4, Dc=-1.627 g·cm^-3, F（000）= 1 984. R1=0.054 0, wR2=0.150 3 （I〉2σ（I））. In the title compound, four chloride ions are coordinated to the cadmium ion forming a slightly distorted tetrahedron. Both Ciprofloxacin and the compound were assayed against grampositive and gram-negative bacteria by doubling dilutions method, the compound shows the same minimal inhibitory concentration （MIC） as the Ciprofloxacin against S. A ureus, M. Lutens, E. Coli and P. Aeruginosa bacteria. The inhibitory effect of the two compounds on leukemia HL-60 cell line has been measured by using MTT （Methyl-Thiazol-Tetrozolium） assay method. The results indicate that the complex has very strong inhibitory effect on HL-60 cell line. CCDC： 259367.
出处
《无机化学学报》
SCIE
CAS
CSCD
北大核心
2005年第9期1363-1366,共4页
Chinese Journal of Inorganic Chemistry
基金
国家自然科学基金项目(No.50073019)
浙江省教育厅科研项目(No.G2040417)资助
关键词
镉(Ⅱ)化合物
环丙沙星
晶体结构
抗菌与抗肿瘤活性
cadmium compound
ciprofloxacin
crystal structure
antibacterial and antitumor activity
