摘要
药代动力学和药效动力学共同构成了现代药理学研究的基础。PK/PD模型是将两者相结合,以说明给予某一剂量后所引起的药理作用的时间过程。研究PK/PD关系不但有助于正确指导临床用药,还可以用于探讨药物作用机制、新药评估以及新制剂的开发等。本文就近些年来PK/PD模型在药理学和毒理学,临床应用以及新药开发等方面的研究进展作一简要的综述。
Pharmacokinetics and pharmacodynamics constitute the foundation of modern pharmacology. PK/ PD modeling is to profile the time process of pharmacological effects after a certain dosage is given. Investigating the relationship between PK and PD is helpful not only in instructing the clinical application, but also in the evaluation of new drugs and exploitation of new preparations etc. The present situation concerning the application of PK/PD modeling in the pharmacology, toxicology and development of new medicine is reviewed.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2005年第8期918-922,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助课题(No30271606)
