摘要
目的:测定风湿性心脏病患者在风湿热静止后血浆中可溶性细胞间黏附分子-1(s-ICAM-1)、可溶性血管细胞间黏附分子-1(s-VCAM-1)和血管性血友病因子(vWF)含量,为研究风湿性心脏病瓣膜和心肌损害过程提供理论依据。方法:空腹抽取40例风湿性心脏病患者和40例健康对照人群的外周静脉血,用酶联免疫吸附法测定血浆中s-ICAM-1,s-VCAM-1和vWF含量。结果:风湿性心脏病患者血浆中s-ICAM-1,s-VCAM-1,vWF浓度都高于健康人群(P<0.01);而且风湿性心脏病房颤患者血浆中s-ICAM-1浓度高于风心病无房颤患者(P<0.05)。结论:风湿性心脏病患者在风湿热静止后心脏瓣膜和心肌的损害与高表达的s-ICAM-1,s-VCAM-1和vWF水平有关。
Objective To measure the concentrations of soluble intercellular adhesion molecule-1 （s-ICAM-1）, soluble vascular cell adhesion molecule-1 （s-VCAM-1）, and yon Willebrand factor （vWF） in the plasma of patients with rheumatic heart disease （RHD）, and to provide basic theory for the mechanism of valvular and myocardial damage. Methods The consecutive patients with RHD （n=40） and healthy people （n=40） were chosen. All blood samples were taken from the peripheral veins. s-ICAM-1 ,s-VCAM-1 and vWF levels in all samples were measured by enzyme-linked immunosorbant as- say. Results s-ICAM-1, s-VCAM-1 and vWF levels were significantly elevated in patients with RHD compared with healthy people （P 〈 0.01 ）. The level of sICAM-1 was elevated in patients with atrial fibrillation compared with patients without atrial fibrillation. Conclusion The concentrations of s-ICAM-1, s-VCAM-1 and vWF levels were significantly elevated in patients with static rheumatic fever, which might be one of the pathogenic： mechanisms of valvular damage, endothelial dysfunction, and myocardial damage in rheumatic heart disease.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2005年第4期407-409,共3页
Journal of Central South University ：Medical Science
关键词
风湿性心脏病
细胞间黏附分子-1
血管细胞间黏附分子-1
血管性血友病因子
房颤
rheumatic heart disease
soluble intercellular adhesion molecule-1
soluble vascular cell adhesion molecule-1
von Willebrand factor
atrial fibrillation
