摘要
目的探讨过敏性鼻炎对鼻息肉手术疗效的影响及其免疫病理机制分析。方法采用免疫组化SP法检测40例鼻息肉(其中单纯性鼻息肉22例,鼻息肉伴过敏性鼻炎18例)和10例中鼻甲黏膜组织中总IgE阳性细胞表达情况;采用Chromotrope2R特染方法检测以上样本中嗜酸性粒细胞(eosinophils,Eos)浸润情况。结果①功能性内镜鼻窦手术(functionalendoscopicsinussurgery,FESS)术后6个月疗效观察显示鼻息肉伴过敏性鼻炎组的总有效率(55.6%)明显低于单纯鼻息肉组(90.9%,P<0.05)。②鼻息肉伴过敏性鼻炎组的总IgE阳性表达率明显高于单纯鼻息肉组(P<0.005)。③鼻息肉伴过敏性鼻炎组的Eos浸润水平明显高于单纯鼻息肉组(P<0.001)。结论鼻息肉病人如果伴有过敏性鼻炎,即IgE介导的Ⅰ型变态反应性炎症,则可增加病情的严重性和复杂性,可作为疗效判断的指标之一。
Objective To explore the influence of an allergic rhinitis on the operation effect of nasal polyps 22 simple nasal polyps, 18 nasal polyps with allergi rhinitisp and study its immunopathogenesis. Methods Fourty patients with nasal polyps （22 simple nasal polyps, 18 nasal polyps with allergic rhinitis and 10 control cases normal mucoca of middle turbiuate were chosen. All samples were stained with SP immunohistochemical and Chromotrope 2R histochemical methods separately to examine total IgE^＋ cells and eosinophil in nasal polyps. Results ① After 6 months of FESS, the total effective rate of nasal polyps accompanied with allergic rhinitis （55.6 % ） was signifancantly lower than that of simple nasal polyps （90.9%, P 〈0.05）. ② The rate of total IgE^＋ cells in the nasal polyps accompanied with allergic rhinitis （77.8%） was significantly higher than that of simple nasal polyps （40.9%, P 〈0. 005）. ③ The level of eosinophils in the nasal polyps accompanied with allergic rhinitis was significantly higher than that of simple nasal polyps （ P 〈 0. 001）. Conclusion Nasal polyps accompanied with allergic rhinitis, i.e. Type Ⅰ allergic reaction mediated by IgE, may increase the severity and complexity of nasal polyps, and may be one of the important marks reflecting the curative effect.
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
2005年第4期225-228,共4页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
