摘要
目的探讨胎盘葡萄糖转运蛋白(glucosetransporter,GLUT)的表达在胎儿生长受限(fetalgrowthrestriction,FGR)发生发展中的作用及其与孕妇血清皮质醇(cortisol,CORT)水平的相关性。方法用免疫组织化学法检测20例FGR孕妇(FGR组)及24例正常妊娠孕妇(对照组)胎盘GLUT1的表达。利用放射免疫分析法测定两组孕妇产前血清CORT水平。同时测量新生儿出生体重和胎盘重量。结果FGR胎盘GLUT1表达水平(149.8±8.2)较对照组(155.9±6.5)明显降低(P<0.05),胎盘合体滋养层基底膜面GLUT1的表达水平(135.3±4.2)较对照组(153.9±8.5)明显降低(P<0.01)。胎盘GLUT1表达水平与孕妇血清CORT水平呈负相关(r=-0.803,P<0.01)。结论胎盘组织中,特别是基底膜面的GLUT1表达水平下降可能是FGR的病因之一,CORT可能通过抑制胎盘GLUT1的表达,参与FGR的发病过程。
Objective To explore the effect of glucose transporter（GLUT） expression in human term placenta when complicated with fetal growth restriction （FGR） and its correlation with maternal serum cortisol level. Methods Twenty pregnant women with FGR and 24 normal pregnant control were selected. The distribution of GLUT1 in human placenta was detected by immunohistochemistry and the serum cortisol level by radioimmunoassay before delivery. The birth weight and the placental weight were measured at delivery. Results The expression of GLUT1 in FGR group was lower than that of the control （149.8±8.2 vs 155.9±6.5, P〈0.05）, and was significantly lower than that of the control in basal membranes of syncytial barrier （135.3±4.2 vs 153.9±8.5 ,P〈0. 001）. Negative correlation was shown between the GLUT1 expression and maternal serum cortisol level （r=-0. 803, P〈0.01）. Conclusions The reduced expression of GLUT1 in placenta may be one of the factors contributing to FGR. Cortisol might take part in the occurrence and development of FGR through inhibiting the placental GLUT1 expression.
出处
《中华围产医学杂志》
CAS
2005年第4期226-229,共4页
Chinese Journal of Perinatal Medicine
