摘要
目的比较术后患者自控镇痛(PCA)单纯用曲马多与曲马多加氟哌利多的镇痛效果和不良反应。方法对80例择期手术患者进行随机、双盲研究,将其分成2组:单纯曲马多组(Ⅰ组)40例,PCA单次给药量曲马多2ml;曲马多+氟哌利多组(Ⅱ组)40例,PCA单次给药量曲马多+氟哌利多2ml;锁定时间均为30min。于术后24、48h分别观察患者的血压、心率、呼吸频率、疼痛评分(VAS)、恶心、呕吐、镇静评分、复视、眩晕、口干和出汗等不良反应。结果两组患者的VAS评分相似,差异无统计学意义(P>0.05);Ⅱ组患者恶心、呕吐的发生率明显低于Ⅰ组患者,差异有统计学意义(P<0.01);两组之间镇静等不良反应、按压次数、镇痛药物用量以及生命体征差异无统计学意义(P>0.05)。结论术后PCA采用曲马多复合氟哌利多可提供与单纯曲马多同样的镇痛效果,但恶心、呕吐明显降低,并且不增加镇静效果。术后PCA采用曲马多复合氟哌利多效果优于单纯曲马多。
Objective To compare the clinical efficacy and side effecs of tramadol and the mixture of tramadol and droperidol for postoperative patient- controlled analgesia（PAC） .Methods Eighty patients,scheduled for elective orbital operation with inhalation general anesthesia（induced with fentanyl, midazolam and etomidate, maintained with isoflurane supplemented by intermittent iv fentanyl and vercuronium for muscle relaxation） were allocated into 2 groups 40 patients each in a random and double blind manner： group Ⅰ （2 ml tramadol） and group Ⅱ （2 nd tramadol plus droperidol）, both with a lockout time of 30 minutes. The VAS, analgesic doses, and side effects were observed 24 and 48 hours after operation. Results Adequate analgesia was achieved with tramadol or the mixture of tramadol and droperidol. The nausea rates and vomiting rates at any time point in the group Ⅱ were all significantly lower than those in the group Ⅰ （all P 〈 0.01 ）. No significant differences in VAS, sedation score or vital signs were observed （all P 〉 0.05）. Contusions Providing a similar quality of analgesia with less nausea and vomiting and little need for sedative, the combination of tramadol and droperidol is superior to tramadol alone for post - operative PCA.
出处
《武警医学》
CAS
2005年第8期575-578,共4页
Medical Journal of the Chinese People's Armed Police Force
