摘要
目的比较加替沙星与环丙沙星对社区获得性感染常见致病菌的体外抗菌活性.方法采用琼脂稀释法测定药物对172株临床分离菌株的最低抑菌浓度.结果革兰阴性菌中,ESBLs(-)肺炎克雷伯菌、铜绿假单胞菌、肠杆菌属对2种药物的敏感率均在90%以上;大肠埃希菌、ESBLs(+)肺炎克雷伯菌、变形杆菌对2种药物的敏感率相对较低,但也在70%以上;不动杆菌、沙雷菌属的MIC90为1～2μg·ml-1;革兰阳性菌中,葡萄球菌属的敏感率较高,其中对加替沙星的敏感率为96.2%,高于环丙沙星的88.5%.链球菌属对加替沙星与环丙沙星的敏感性差.结论加替沙星与环丙沙星对社区获得性感染常见致病菌有较强的抗药活性.
Aim To evaluate the antibacterial activity of gatifloxacin compared with ciprofloxacin against common isolates in vitro. Methods Minimal Inhibitory Concentrations （MIC） were determined by agar dilution method. Results Among G^-, the susceptible rate of K. pnetunoniae （ ESBLs - ）, P. aemginosa, Enterobacter was over 90%, while it was over 70% among E. coli, K. pnetunoniae （ ESBLs ＋ ） and bacillus proteus. The MIC90 of Acinetobacter and Serratia was 1-2μg·ml^-1. Among G^＋ , the susceptible rate of gatifloxacin against Staphylococcus （96.2%） was higher than that of ciprofloxacin （88.5 % ）, while Streptococcus was not susceptive to both gatifloxacin and ciprofloxacin. Conclusion Compared with eipmfloxaein, gatifloxacin has a powerful antibacterial activity to pathogen from community acquired infections.
出处
《解放军药学学报》
CAS
2005年第4期309-312,共4页
Pharmaceutical Journal of Chinese People's Liberation Army
关键词
加替沙星
环丙沙星
常见致病菌
Gatifloxacin
Ciprofloxacin
Antimicrobial resistance
