摘要
目的观察整合素αVβ3在不同级别脑胶质细胞瘤和对照脑组织中的表达,探讨整合素对胶质细胞瘤侵袭性的影响。方法选择经过病理学检查证实的胶质细胞瘤患者48例,其中胶质细胞瘤Ⅱ级病人22例,Ⅲ级病人12例,Ⅳ级病人14例。选择外伤手术切除的挫裂伤脑组织作为对照标本,共13例。用整合素αVβ3抗体对标本进行免疫组化染色。结果对照组脑组织、低级别胶质瘤和高级别胶质瘤细胞中整合素αVβ3的阳性表达依次增高,并且差异有统计学意义。结论整合素的阳性表达率与胶质细胞瘤的恶性程度呈正比,在胶质细胞瘤的发展和侵袭中起重要作用。
Objective To observe the expression of integrin αVβ3 in glioma and normal brain tissue and to discuss the effect of integrin αVβ3 on the invasion of gliomas. Methods 48 cases of glioma were verified by pathological study, including 22 cases of grade Ⅱ , 12 cases of grade Ⅲ , and 14 cases of grade Ⅳ. 13 cases of normal brain tissues were obtained from the removed brain tissues of patients who were injured. Antibody of integrin αVβ3 was used to stain glioma and normal brain tissues. Results In brain tissues, low grade gliomas and high grade gliomas, the expression of integrin αVβ3 became more and more stronger and there was statistical significance too. Conclusion Expression of integrin αVβ3 has a positive correlation with the malignant degree of gliomas. Integrins has a great effect in the development and invasion of gliomas.
出处
《首都医科大学学报》
CAS
2005年第4期389-391,共3页
Journal of Capital Medical University
