摘要
本文通过油酸酰氯强活性中间体合成了维生素E油酸酯。对影响维生素E油酸酯产率的因素-原料配比、溶媒用量、反应温度和反应时间等四个因素进行了分析,采用L16(45)正交设计进行优化,并采用TLC和HPLC法对产品进行了分析。最佳合成工艺为:油酸酰氯与维生素E的摩尔配比为3:1,催化剂吡啶用量为0.025ml,反应时间4h,温度45℃,反应转化率为41.8%。
This article gave a way of synthetizing the vitamin E oleate by using oleic chloride and α -tocopherol. Through orthogonal experiments, the reaction was carded out in non-aqueous medium with methylene chloride as solvent and pyridine as catalyst. The influence of the initial molar ratio of substrates, the amount of catalyst, reaction temperature and time was investigated, and the vitamin E oleate product was analysed by TLC and HLCP. The optimum of reaction conditions were established as follow： at 45 ℃, vitamin E （ α -tocopherol ）/oleic chloride （mol/mol） =3： 1, in the presence of 0.025ml the pyridine as catalyst, vitamin E oleate yield reached 41.8% after 4h of reaction.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2005年第8期135-138,共4页
Food Science
基金
国家863计划项目(2004AA2Z3490)
广西教育厅科研项目(2003812)
