摘要
目的:探讨慢性心力衰竭(CHF)患者卡维地洛治疗前后血浆脑钠素(BNP)浓度的变化。方法:用放射免疫法测定56例CHF患者(CHF组)治疗前、后及60例体检健康者(对照组)的血浆BNP浓度;用放射性核素99m锝心血池扫描测定CHF患者治疗前、后左心室射血分数(LVEF)。结果:CHF患者血浆BNP浓度(222.65±78.52)ng/L显著高于对照组(38.82±15.31)ng/L(P<0.01),且随着心功能分级的程度加重而增加。血浆BNP浓度与LVEF之间存在良好的负相关(r=-0.68,P<0.01)。卡维地洛治疗3个月后血浆BNP浓度由(222.65±78.52)ng/L降至(79.65±69.52)ng/L(P<0.01);LVEF由(34.41±4.54)%升至(46.51±5.38)%(P<0.01)。结论:CHF患者血浆BNP浓度升高,且随CHF严重程度的增加而显著升高;卡维地洛可使CHF患者血浆BNP浓度显著降低,且能改善左心室功能状态。
Objectivt： To investigate the changes of plasma brain natriuretic peptide（BNP） levels in patients with chronic heart failure（CHF） after carvedilol treatment. Method： Plasma BNP concentrations of patients with CHF（ n =56） before and after carvedilol treatment and of normal controls （ n =60） were measured with specific radioimmunoassay, Left ventricular election fraction of patients with CHF before and after carvedilol was measured with ^99m Tc gated cardiac blood pool scintigraphy, Result： The results showed that plasma BNP concentrations of patients with CHF were significantly higher than normal controls [ （222.65±78.52） vs （38.82±15. 31 ）ng/ L, P 〈0.01]. Plasma BNP concentrations had a significant negative correlation with left ventricular ejection fractions （ r=-0.68, P〈0.01）. After three months treatment of carvedilol, plasma BNP levels fell to （79.65±69. 52）ng/L（ P 〈0. 01） ,left ventricular ejection fractions increase from （34.41±4. 54） to （46. 51±5. 38）%（ P 〈 0.01 ）. Conclusion：These results indicate that plasma BNP levels increased in patients with CHF, and markedly increased according to the severity of heart failure classified by NYHA classification. Carvedilol can markedly decrease plasma BNP levels and improve left ventricular function in patients with CHF.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2005年第8期468-469,共2页
Journal of Clinical Cardiology
关键词
心力衰竭
充血性
脑钠素
卡维地洛
Heart failure, congestive
Brain natriuretic peptide
Carvedilol
