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富含半胱氨酸的分泌型酸性蛋白与肿瘤的关系 被引量：4

Relationship of secreted acidic protein rich in cysteine and tumor
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摘要 富含半胱氨酸的分泌型酸性蛋白(SPARC)是一种调节细胞外基质的糖蛋白,与某些基质成分、生长因子和细胞因子作用,参与组织重建、形态生成、细胞迁移和增殖,调节机体的生理和病理过程。现就其分子结构、生物学功能、相应机制、表达调节及与肿瘤的发生、发展、侵袭和转移的关系等作一简述。
作者 毕薇薇 车轶群 李振家
机构地区 吉林省四平市中心医院检验科 中国医学科学院肿瘤医院检验科
出处 《国外医学（临床生物化学与检验学分册）》 2005年第8期551-552,共2页 Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
关键词 半胱氨酸 分泌型酸性蛋白 肿瘤 糖蛋白 病理机制 细胞迁移
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献10

  • 1Sasaki T,Miosge N,Timpl R.Immunochemical and tissue analysis of protease generated neoepitopes of BM-40 (osteonectin, SPARC) which are correlated to a higher affinity binding to collagens. Matrix Biol, 1999, 18(5): 499-508.
  • 2Bork P, Downing AK, Kieffer B, et al. Structure and distribution of modules in extracellular proteins. Q Rev Biophys, 1996, 29(2): 119-167.
  • 3Massi D, Franchi A, Borgognoni L, et al. Osteonectin expression correlates with clinical outcome in thin cutaneous malignant melanomas. Hum Pathol, 1999, 30(3): 339-344.
  • 4Rempel SA, Ge S, Gutierrez JA. SPARC: a potential diagnostic marker of invasive meningiomas. Clin Cancer Res, 1999, 5(2): 237-241.
  • 5Briggs J, Chamboredon S, Castellazzi M, et al. Transcriptional upregulation of SPARC, in response to c-Jun overexpression, contributes to increased motility and invasion of MCF7 breast cancer cells. Oncogene, 2002, 21(46): 7077-7091.
  • 6De S, Chen J, Narizhneva NV, et al. Molecular pathway for cancer metastasis to bone. J Biol Chem, 2003, 278(40): 39044-39050.
  • 7Chlenski A, Liu S, Crawford SE, et al. SPARC is a key Schwannian-derived inhibitor controlling neuroblastoma tumor angiogenesis. Cancer Res, 2002, 62(24): 7357-7363.
  • 8Golembieski WA, Rempel SA. cDNA array analysis of SPARC-modulated changes in glioma gene expression. J Neurooncol, 2002, 60(3): 213-226.
  • 9Yamashita K, Upadhay S, Mimori K, et al. Clinical significance of secreted protein acidic and rich in cystein in esophageal carcinoma and its relation to carcinoma progression. Cancer, 2003, 97(10): 2412-2419.
  • 10Yamanaka M, Kanda K, Li NC, et al. Analysis of the gene expression of SPARC and its prognostic value for bladder cancer. J Urol, 2001, 166(6): 2495-2499.

同被引文献58

  • 1耿文君.SPARC研究进展[J].生命科学仪器,2009,7(2):7-10. 被引量：7
  • 2王文靖,梅长林,孙田美,汤兵,李占园,徐成钢.富含半胱氨酸的酸性分泌糖蛋白对囊肿衬里上皮细胞细胞周期及其调控基因表达的影响[J].中华肾脏病杂志,2005,21(2):108-111. 被引量：3
  • 3崔永,王天佑.SPARC与恶性肿瘤[J].中华医学杂志,2005,85(9):642-644. 被引量：4
  • 4Xia Q Y,Zhou Z Y,Lu C,et al.A draft sequence for the genome of the domesticated silkworm (Bombyx mori)[J].Science,2004,306(5703):1937-1940
  • 5Xia Q Y,Wang J,Zhou Z Y,et al.The genome of a lepidopteran model insect,the silkworm Bombyx mori[J].Insect Biochem Mol Biol,2008,38(12):1036-1045
  • 6Watson K,Edwards R J.HIV-1-trans-activating (Tat) protein:both a target and a tool in therapeutic approaches[J].Biochem Pharmacol (Review),1999,58(10):1521-1528
  • 7Kireeva M L,Mo F E,Yang J P,et al.Cyr61,a product of a growth factor-inducible immediate-early gene,promotes cell proliferation migration and adhesion[J].Mol Cell Biol,1996,16 (4):1326-1334
  • 8Bable A M,Kirceva M L,Kolesnikova T V,et al.Cyr61,a product of a growth fatter-inducible immediate early gene,promotes angiogenesis and tumor growth[J].Proc Natl Acad Sci USA,1998,95 (11):6355-6360
  • 9Jiang W G,Watkins G,Fodstad O,et al.Differential expression of the CCN family members Cyr61,CTCF and Nov in human breast cancer[J].Endoer Relat Cancer,2004,11:781-791
  • 10Xie D,Yin D,Wang H J,et al.Levels of expression of Cyr61 and CTGF are Prognostic for tumor progression and survival of individuals with glimes[J].Clin Cancer Res,2004,10:2072-2081

引证文献4

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国外医学（临床生物化学与检验学分册）
2005年 第8期

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