摘要
α-生育酚琥珀酸酯(α-tocopherol succinate)是天然维生素E的衍生物,它是由琥珀酸与α-生育酚的β-色酮环的6位羟基成酯而形成的化合物(图1),由于丧失了自由的羟基而不具有维生素E的抗氧化活性,在空气中较为稳定,因其可保护α-生育酚的6位羟基,使α-生育酚在储存和运输中稳定性增加,而广泛用于α-生育酚的运输和储存[1].
A purified α-tocopherol succinate was obtained using an enzymatic selective hydrolysis method. β- tocopherol succinate and γ- tocopherol succinate in vitamin E succinate was selectively hydrolyzed using CRLA fraction of commercial CRI. （Candida rugosa lipase） to produce hydrophilic succinic acid and hydrophobic β- and γ- tocopherol. Removal of the β- and γ- tocopherol from lesser hydrophobic residue substrate α-tocopherol succinate with SiO2 column chromatography resulted in purification of α-tocopherol succinate. The effects of water content in the reaction medium, and reaction time on the hydrolysis conversion and purity of α-tocopherol succinate have been investigated. When the reaction time was 144 h, the hydrolysis conversion is 18. 5%, the content of α-tocopherol succinate in the residual substrate increased from 81. 6 to about 97.0%. The content of α-tocopherol succinate in the residual substrate increased slightly but the hydrolysis conversion increased obviously when the reaction time was further prolonged.
出处
《分子催化》
EI
CAS
CSCD
北大核心
2005年第4期285-288,共4页
Journal of Molecular Catalysis(China)
基金
国家自然科学基金重点项目(编号:29933040)
黑龙江省自然科学基金(编号:B2004-03)
哈尔滨市科学基金(编号:2004AFXXJ031)
黑龙江省教育厅项目.
