摘要
本文33例有冠心病家族史(观察组)与174的无冠心病家族史(对照组)的足月健康新生儿血清胆固醇(TC)、甘油三酯(TG)、载脂蛋白AI(ApoAI)、载脂蛋白B(ApoB)、脂蛋白(a)[LP(a)]测定值的水平比较发现,观察组ApoB均值明显高于对照组(P=0.0015),有高度显著性差异;观察组LP(a)均值及浓度增高频率均明显高于对照组(P分别<0.05,0.01),有显著性差异。表明ApoB、LP(a)有明显的遗传倾向,是筛查新生儿脂质异常的可靠指标.同时也表明,有冠心病家族史的新生儿发生冠心病的危险性显著增加.新生儿脂质异常的筛查工作,是减少冠心病发病率的重要手段之一。
Lipid and apolipoprotein levels of 33 full-term neonats with family history of coronary heart disease and 174 without such a history were studied. The results show that apolipoprotein B and lipoprotein(a) levels ( x ?S ) are significantly higher in group with family history than in group without family history ( P <0. 05);also in the group with family history,there is a hiigher elevated lipoprotein(a) (≥95th Percentile) frequency ( P <0. 01). Our data suggested that there is a strong heritability for ApoB and Lp (a). Therefore, they are dependable indexes for screening for lipids abnormalitier in new-borns.
关键词
新生儿
脂质异常
冠心病
筛查
Newborn Lipid abnormalities Coronary heart disease Screening
