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脑损伤后COX-1和COX-2的表达 被引量：1

The Expression of COX-1 and COX-2 Following Brain Injuries
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摘要 环加氧酶(cyclooxygenase,COX)是催化花生四烯酸(arachidonic,AA)合成前列腺素(prostaglandin,PG)的限速酶。后者在调节有丝分裂、凋亡、血管生成、血流动力学、继发性脑损伤及炎症反应等过程中发挥重要作用。COX有两种亚型:COX-1和COX-2。近年来研究证实,COX-1和COX-2在脑损伤过程中扮演了重要的角色。 Cyclooxygenase （COX） is the obligate, rate-limiting enzyme for the conversion of arachidonic acid into prostaglandins, which mediate mitogenesis, apoptosis, angiogenesis, blood flow, secondary injury, and inflammation. COX is consi st of 2 subtypes： COX-1 and COX-2. In recent years, there are a number of lines of evidence that COX-1 and COX-2 play a important in role brain injuries.
作者 郭学荣 周亦武 马艺列 李振营 李欣 刘良
机构地区 广州市公安局广州经济技术开发区分局刑警大队 华中科技大学同济医学院法医学系
出处 《法医学杂志》 CAS CSCD 2005年第3期223-225,共3页 Journal of Forensic Medicine
基金 湖北省自然科学基金(2003ABA140) 中国博士后基金资助项目(2003034459)
关键词 环加氧酶 脑损伤 损伤时间 前列腺素 血流动力学 cyelooxygenase brain injury post injury time
分类号 D919 [医药卫生—法医学]
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参考文献17

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同被引文献11

  • 1高彬昌,栾红,李琴.肌苷对缺氧缺血性脑病新生鼠脑组织环氧合酶、钙调神经磷酸酶表达的影响[J].中华围产医学杂志,2006,9(2):125-126. 被引量：1
  • 2Namita Kundu, Tonya C, Walser, et al. Cancer Immunology [ J ], Immunotherapy,2005,54:201 - 210.
  • 3Kim S S, Kong P J, Kim B S, et al. Inhibitory action of minocycline on lipopolysaccharide-induced release of nitric oxide and prostaglandin E2 in BV2 microglial cells [ J ]. Arch Pharm Res, 2003,57 ( 3 ) :295-303.
  • 4De Cristobal J, Cardenas A, Lizasoain I, et al. Inhibition of glutamate release via recovery of ATP levels accounts for a neuroprotectire effect of aspirin in mt cortical neurons exposed to oxygen-glucose deprivation [ J ]. Stroke, 2002,33 ( 1 ) : 261-267.
  • 5Kinoshita Y, Ueyama T, Senba E, et al. Expression of c-fos, heat shock protein 70, neurotrophins, and cyclooxygenase-2 mRNA in response to focal cerebral ischemia/reperfusion in rats and their modification by magnesium sulfate [ J ]. J Neurotrauma, 2001,18 (4) :435--445.
  • 6Schwab J M, Seid K, Schluesener H J. Traumatic brain injury induces prolonged accumulation of cyclooxygenase-1 expressing microglia/brain macrophages in rats [ J]. J Neurotrauma, 2001,18 (9) :881-890.
  • 7Strauss K I, Barbe M F, Marshall R M,et al. Prolonged cyclooxygenase-2 induction in neurons and glia following traumatic brain injury in the rat[J]. J Neurotraama,2000,17(8) :695-711.
  • 8Kunz T, Marklund N, Hillered L, et al. Cyclooxygenase-2, prostaglandin synthases, and prostaglandin H2 metabolism in traumatic brain injury in the rat [ J ]. J Neurotrauma, 2002,19 ( 9 ) : 1051 - 1064.
  • 9Seidberg N A, Clark R S, Zhang X, et al. Alterations in inducible 72-kDa heat shoek protein and the chaperone cofactor BAG-1 in human brain after head injury[J]. J Neuroehem. 2003,84(3): 514-521.
  • 10吴旭,汪德文,张国华,陈怀芳,任立国,单亚明.定量检测NSE和S-100推断脑挫伤时间的动物实验[J].中国法医学杂志,1999,14(3):141-144. 被引量：16

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法医学杂志
2005年 第3期

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