摘要
目的探讨血浆Aβ变量(Aβ40、Aβ42水平及其比值)在正常衰老和阿尔茨海默病(AD)疾病过程中的变化规律及对AD其诊断价值。方法双抗体夹心ELISA检测113例AD患者和205例不同年龄段健康者的血浆Aβ水平并分析其与AD临床的相关关系。结果在正常衰老过程中Aβ40和Aβ42水平呈现相反的变化曲线。AD患者Aβ40水平显著高于与其年龄匹配的正常老年组(P=0.002),而Aβ42水平却显著低于后者(P<0.001),但在AD自然病程中Aβ变量没有明显改变。ROC分析表明:以aNC组Aβ比值的x+2s(15.9)为截断点时,其对AD诊断的敏感度和特异度分别为24%和96%。结论血浆Aβ变量呈现年龄和疾病相关性变化,其中Aβ比值有助于AD的临床诊断。
Objective To investigate the changing model of plasma Aβ variables （Aβ40, Aβ42） and Aβ40/Aβ42 ratios during normal aging and the natural course of Alzheimer＇ s disease （AD）, and their clinical values for AD diagnosis. Methods A specific sandwich ELISA was employed to measure plasma AI340 and AI342 levels of 113 AD cases and 205 normal controls aged from 1 to 91 years old. AD clinical data was related with the above Aβ variables. Results Plasma Aβ40 levels increased with normal aging, but AI342 levels kept almost unchanged during the whole course of aging. A significantly elevated Aβ40 level （P=0.002） and a significantly lowered Aβ42 level （P〈0.001） was found in the AD group, contrasted with aged-matched controls. However, all Aβ variables were unchanged during natural course of AD. ROC analysis produced a cutoff value （15.9） ofAβ40/Aβ42 ratios with a sensitivity of 24% and a specificity of 96% for AD diagnosis. Conclusion The changing models of plasma Aβ variables are ageand AD-related, and Aβ ratio is one of useful biomarkers for AD diagnosis.
出处
《中华神经医学杂志》
CAS
CSCD
2005年第8期766-768,共3页
Chinese Journal of Neuromedicine
基金
广东省医学科研基金(20055568)
