摘要
喹唑啉酮类化合物是一类具有良好生物活性的含氮杂环化合物.以4-氯-2-硝基苯甲酸为原料经过酯化、酰胺化、硝基还原合成了中间体2-氨基-4-氯苯甲酰胺.2-氨基-4-氯苯甲酰胺和对三氟甲基苯甲酰氯经过两步反应合成了7-氯-2-(4-三氟甲基苯基)喹唑啉-4(3H)-酮,再与吗啉反应得到目标化合物7-吗啉-2-(4-三氟甲基苯基)喹唑啉-4(3H)-酮,总产率34.90%.并通过红外光谱与核磁确定目标化合物的结构.
Quinazoline derivatives are a class of compounds with good biological activity of nitrogen containing heterocyclic compounds.In this article,the intermediate 2-amino-4-chlorobenzamide was synthesized from 4-chloro-2-nitrobenzoic acid,through esterification with methanol,followed by amidation with ammonium hydroxide,reduction with Iron powder and hydrochloric acid.2-amino-4-chlorobenzamide reacted with 4-(trifluoromethyl) benzoyl chloride to afford 7-chloro-2-(4-(trifluoromethyl) phenyl)quinazolin-4(3H)-one.The target compound 7-morpholino-2-(4-(trifluoromethyl) phenyl) quinazolin-4(3H)-one was synthesized through a condensing reaction between the intermediate 7-chloro-2-(4-(trifluoromethyl) phenyl) quinazolin-4(3H)-one and morpholine.The total yield of 9 is 34.90%.The structure of the target compound was confirmed by IR and 1HNMR.
出处
《辽宁大学学报（自然科学版）》
CAS
2011年第3期251-254,共4页
Journal of Liaoning University：Natural Sciences Edition
关键词
喹唑啉酮
生物活性
合成
quinazolinone
biological activity
synthesis
