摘要
目的 观察雷莫司琼不同给药时机预防患者甲状腺术后恶心、呕吐(PONV)的效果.方法 将60例在气管插管全身麻醉下行甲状腺次全切除术的患者随机分为三组,每组20例.雷莫司琼术前用药组(Ⅰ组),于麻醉诱导前给予雷莫司琼0.3 mg;雷莫司琼术后给药组(Ⅱ组),于手术结束时给予雷莫司琼0.3 mg;对照组(Ⅲ组),给予生理盐水5 ml作对照.观察记录患者术后24 h内恶心、呕吐发生情况.结果 Ⅰ组术后0～6 h和7～24 h两时段内恶心、呕吐发生率为30%和15%,Ⅱ组为35%和20%,Ⅰ组与Ⅱ组比较差异无统计学意义(P＞0.05),但均随时间推移PONV有显著降低(P < 0.05);Ⅲ组两时段内恶心、呕吐发生率为65%和50%,Ⅰ组、Ⅱ组与Ⅲ组同时段比较差异均有统计学意义(P＜0.05).结论 雷莫司琼在剂量相同的条件下,术前和术后两种不同时机给药均能有效地减少术后恶心、呕吐的发生,术前给药似乎效果更优.
Objective To study the effects of ramosetron on postoperative nausea and vomiting (PONV) after thyroid gland surgery.Methods Sixty patients, ASA score Ⅰ-Ⅱ, scheduled for elective thyroid gland surgery were randomly allocated into three groups: preoperative group (group I,n=20),ramosetron was given prior to the inductional anesthesia; postoperative group (group Ⅱ,n=20),ramosetron was given at the end of the surgery; control group (group Ⅲ,n=20), no ramosetron was given. The accidence of PONV was obversed, the numbers of patients with PONV and side effects were recorded during 24 h after surgery respectively. Results The frequency of PONV was 30% and 15% on 0-6 h and 7-24 h respcetively in gloup I,35% and 20% in group Ⅱ and 65%and 50% in group Ⅲ.There was no significantly difference between group Ⅰ and group Ⅱ(P>0.05), and were significantly differences between group Ⅲ and group Ⅰ or group Ⅱ(P<0.05).Conclusions Under the same dose,ramosetron given either before surgery or after surgery can effectively reduce the occurence of PONV,it seems that the former is better.
出处
《中国实用医刊》
2010年第15期24-25,共3页
Chinese Journal of Practical Medicine
关键词
术后恶心呕吐
甲状腺手术
雷莫司琼
全身麻醉
Postoperative nausea and vomiting
Thyroid gland surgery
Ramosetron
General anesthesia
