摘要
为探讨宫颈癌病毒病因中人乳头瘤病毒(HPV)和包疹病毒II型(HSV-2)的可能作用,我们分则应用DNA杂交技术和免疫组化PAP染色方法,对一系列临床宫颈疾患中HPVDNA和HSV-2抗原进行了检测,分析了两者的相关性。检测结果,宫颈慢性炎症、宫颈不典型增生及宫颈癌中HPV16、18和11型DNA的阳性率分别为13咭、0、18%、17%、17%、17%和43%、8%、4%。且在41%的宫颈慢性炎症、50%的宫颈不典型增生和63%的宫颈癌组织中测到了HSV-2抗原。比较HPV DNA杂交与HSV-2抗原检凝结果,发现部分病例既能测到HPV DNA又可测到HSV-2抗原。结果提示,宫颈癌的病毒病因可能是多因素的,HSV-2和HPV均与宫颈癌有关,两者在宫颈癌的发生过程中或许起协同作用。
HPV DNA and HSV-2 antigens were detected in a series of cervical·lesions by DNAhybridization,and PAP stain techniques in order to investigate the possible role of HPVand HSV-2 in the viral etiology of cervical carcinoma.The correlation of HPV DNAsequence and HSV-2 antigens was analyzed,The results showed that the positive rates ofHPV 16,·18 and 11 in cervicitis,dysplasia and cervical cancer were 13%;0,13%;17%,17%,17%143%,8%,4%;and HSV-2 antigens were found in 41%of cervicitis,50%of cervical dysplasia and 83%of cervical carcinoma.Comparing the rcsults of HPVhybridization with that of HSV-2 antigens,the authors found that both HPV DNA andHSV-2 antigens could be detected in some cases.The results indicate that the viral etio-logy of'cervieal carcinoma may be multifactorial and HSV-2 and HPV may be syner-gistie in the doveloprient of cervical carcinoma.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1989年第2期108-110,共3页
Chinese Journal of Oncology
