摘要
以大肠杆菌、绿脓杆菌、金黄色葡萄球菌免疫羊,取其肝、脾制备免疫核糖核酸。通过动物实验证实了抗菌免疫核糖核酸的免疫活性和抗菌保护作用。95例烧伤病人应用免疫核糖核酸实行分组对照,治疗结果证明,防治革兰氏阴性杆菌感染效果是显著的。
The immune RNA was extracted from the spleens and livers of immunizing sheep with Ps. aeruginorsa, E. coli and S. anreus. After animal trial, the i-RNA activity and its antibacterial protective effect has been demonstrated. 95 cases of burn infection treated with i-RNA plus antibiotics were compared with a concurrent control group treated with antibiotics alone. Clinical observation confirmed that an obvious effect on the prevention and treatment of burn infection with gram negative bacteria was manifested. Among them, 59 cases with burn area 15-49% Ⅱ°, Ⅲ° of total body surface, the ratio of incidence of gram negative septicemia and wound pyemia between i-RNA and control group was 1.69% 22%, p<0.01. In another 36 cases with burn area over 50% body surface Ⅱ°, Ⅲ° treated with i-RNA the gram negative septicemia or wound sepsiswere found in 3 cases(morbidity 8.3%). And one died overall mortality was 2.8%. Whereas, the morbidity and mortality were 51.4% and 45.9% respectively in 37 control cases. The ratio of morbidity between i-RNA and control group was 8.3%: 51.4%, p<0.01, and that of mortality was 2.8%: 45.9%, p<0.01.
