摘要
于４７例受试对象，同时采集冠状静脉窦（ＣＳ）及升主动脉（Ａｏ）血进行血浆及血清凝血烷Ｂ２（血栓素Ｂ２，ＴＸＢ２）及６─酮─前列腺素Ｆ１α（６－ｋｅｔｏ－ＰＧＦ１α）的测定，部分患者同时进行了血浆环磷酸腺苷（ｃＡＭＰ）及血小板聚集性测定。结果表明，不稳定性心绞痛（ＵＡ）患者及急性心肌梗死（ＡＭＩ）患者血浆ＴＸＢ２ＣＳ／Ａｏ比值明显高于正常对照组及稳定性心绞痛（ＳＡ）患者。ＳＡ、ＵＡ及ＡＭＩ患者血清ＴＸＢ２ＣＳ／Ａｏ比值均明显低于正常对照组。ＵＡ患者血浆ｃＡＭＰＣＳ／Ａｏ比值明显低于ＳＡ及正常对照组，ＵＡ与正常对照比较其ＣＳ中血小板聚集性明显低于Ａｏ中者。结果提示，ＵＡ及ＡＭＩ患者冠状循环中血小板明显激活，凝血烷Ａ２（血栓素Ａ２，ＴＸＡ２）大量释放。
Simultaneous coronary sinus(CS) and ascending aorta(AO) blood samples were obtained from 47 patients for measurement of plasma and serum thromboxane B_2 and 6-keto-prostaglandin F_1α. Some samples were also tested for platelet aggregation and plasma cAMP. The results showed (1) patients with unstable angina pectoris (UA , n=20) and acute myocardial infarction(AMI, n=5) had higher plasma TXB_2 CS/AO ratios (1. 66±0. 20 and 2. 32±0. 47, respectively) than patients with stable angina (SA , n=9) and control subjects(n=13, 1.04±0.17 and 1.00 ±0.06,respectively)(p<0. 05); (2) serum TXB_2 CS/AO ratios in patients with SA,UA or AMI were significantly lower when compared with control subjects; (31plasma cAMP CS/AO ratios were lower in patients with UA than those in patients with SA or control subjects;(4) platelet aggregation in CS blood significantly decreased than that in AO blood in patients with UA when compared with control subjects;(5)no significant differences were found in plasma or serum 6-keto-PGF_1α CS/AO ratios among the four groups of patients. The results suggest that platelets are significantly activated in coronary circulation in patients with UA and AMI.
出处
《中国循环杂志》
CSCD
1995年第5期259-262,共4页
Chinese Circulation Journal
基金
国家自然科学基金
关键词
冠心病
血小板
前列腺素
冠状循环
环磷酸腺苷
Coronary heart disease
Platelet
Prostaglandin
c-AMP
Coronary circulation
