摘要
对４０例血压正常的原发性高血压患者子女做运动负荷试验表明，１４例出现运动触发性高血压［≥３０／１２．６ｋＰａ（２２５／９５ｍｍＨｇ）］，其肾素活性、血管紧张索Ⅰ（ＡｎｇⅠ）、血浆５－羟吲哚类物质浓度运动后均较正常血压者升高（Ｐ＜０．０５）；内源性洋地黄因子显著升高（Ｐ＜０．００１），而运动后降低；血小板５－羟色胺运动后降低。高血压患者子女运动后心钠素较对照组升高（Ｐ＜０．０５），６－酮－前列腺素Ｆ１α、凝血烷Ｂ２（ＴＸＢ２，血栓素Ｂ２）无差异。
The blood pressure(BP) responses to exercise of normotensives, aged 27±3 yrs. at high risk(positive parental history of hypertension,n=40) and at low risk(negative parental history of hypertension, n=20) were studied. All had normal body weight and resting blood pressure. During graded bicycle exercise,35% (14/40) of the high risk subjects bad exaggerated BP response[≥30/12. 6 kpa(225/95 mmHg)] versus 0% of the low risk subjects. The changes of some circulating factors to exercise were also evaluated. The PRA and plasma All concentration in exaggerated BP responders rose to maximum at the end of exercise.The plasma endogenous digitalis-like substance (EDLS) in exaggerated BP responders was already elevated before exercise, and decreased by exercise. Plasma atrial natriuretic peptide(ANP) in the high-risk group increased significantly after exercise vs. the lowrisk group, whereas plasma ANP of the high-risk exaggerated responders was the highest.Plasma 6-keto-PGF1a and thromboxane Ba increased with exercise . but no significant difference was found between the 2 groups. Exaggerated response of plasma 5-HT to exercise in exaggerated BP subjects was marked.The platelet 5-HT concentration in exaggerated BP persons was decreased before exercise.
出处
《中国循环杂志》
CSCD
1995年第4期200-202,共3页
Chinese Circulation Journal
