摘要
利用大脑中动脉区实验性脑梗塞模型狗32只,随机分为药物治疗组(甲);药物治疗加4小时重建术组(乙);对照组(丙);单纯4小时重建术组(丁)。对实验动物进行临床观察和24小时处死后脑病理学的研究,结果甲、乙组的临床和神经元缺血损害较丙、丁组轻微,尤以乙组更为显著,经统计学处理差异有显著性(P<0.01)。认为对急性脑缺血早期采用适当剂量的脑保护剂,可有效地减轻脑缺血缺氧状态,降低脑水肿程度,延缓脑梗塞灶形成,为2～4小时脑血管重建术创造有利条件。
Ligation of right MCA was performed in a serles of experimental animal of divided into 4 groups. Group A was treated with perflourotripropylamine FTPA, 20% mannitol, dexamethasone;Group B was treated with FTPA,20% mannitol, dexamethasone and the blood vessel was reconstructed 4 hours later.Group C was control;Group D:of the blood vessels only 4 has later.All of this dogs were sacrificed After 24 hours.There were ischemic neuronal damage in different degree in all specimens under microscope. The results of this experlmental therapeutic research was that the clinical findings of Group A and B were better than Group C and D,and the perceatage of the cerebral ischemic area and volume of ischea(?)ia (%, HAI and %, HVI) were less than Group C and D. There was a statistically significant difference between Group A,B and Group C,D (p<0.05). The combined treatment with FTPS, 20% mannitol and dexamethasone may reduce the degree of cerebral edema, delay the formation of cerebral infarction and provide an opportunity for 2-4 hrs. to reconstruction of the blood supply.
出处
《中华神经外科杂志》
CSCD
北大核心
1989年第1期39-42,共4页
Chinese Journal of Neurosurgery
基金
国家自然科学基金
