摘要
本文采用单克隆ＡＰＡＡＰ技术和常规临床检验法测定２５例肠易激综合征患者即应激组和对照组２１名健康人的外周血液中免疫功能指标。结果：应激组的ＩｇＧ、Ｔ４、Ｔ４／Ｔ８和Ｅｔ花结反应率均比对照组降低；而Ｔ３、Ｔ８值比后者明显增高。经多因素回归分析，生活事件和负性生活事件与Ｔ３高度正相关，与Ｔ４／Ｔ８呈高度负相关，而后果同时又与ＩｇＡ、Ｃ３补体呈显著正相关。上述结果提示了应激状态下存在免疫功能障碍及免疫调控失调。
The immunolgical changes in 25 cases with the irritabble bowel syndrome as stressed group (SG) were compared with that of 21 matched healthy volunteers as control group(CG) in this study.T- lymphocyte subgroup was determined with APPAAP,The result showed the quanity of IgG the numbere of CD4+ (Th) ,the ratio of Th and CD8+(TS),and Et reaction rate in SG was significntly lower thar of in GG, but CD3+(T3)and Ts was markedly higher(P<0.05).Meanwhile,multivariate analysis or MGLH showed that the life change unit(LCU) and 'negative'LCU was positively correlate with the numbers of T3. but negative correlated with the ratio of Th/Ts, and the negative life change unit was also interrelated positively with the quanity of IgA. C3 complemnl. The authors stressed that the significant disorder or abnormallty of human immunological function and immune modulation imbalanced or depresssion of TS enhanced in the periphericcal blood after psychosocial and physical stress,though the results has unclosed.
出处
《中国行为医学科学》
CSCD
1995年第2期80-82,共3页
Chinese Journal of Behavioral Medical Science
关键词
应激
免疫功能
肠疾病
功能性肠疾病
Irritable bowel syndrome Immunoigical function Stress.
