摘要
本文以１５月龄昆明鼠和６０～７２岁老龄人为对象，采用生物学活性检测法观察了北芪对老龄鼠脾细胞受ＣｏｎＡ刺激后产生ＩＬ－２，ＴＮＦ及ＩＦＮ－γ水平的影响，采用ＥＬＩＳＡ双抗体夹心法检测了老龄鼠脾细胞上清中ｓＩＬ－２Ｒ含量。实验结果证明老龄机体ＩＬ－２，ＴＮＦ和ＩＦＮ－γ分泌功能下降，ｓＩＬ－２Ｒ水平增高。服用北芪后明显地提高了老龄机体的ＩＬ－２，ＴＮＦ和ｒＩＦ－γ水平，降低了ｓＩＬ－２Ｒ水平，进而证明北芪是一种良好的免疫增强剂，能增强老龄机体抗肿瘤、抗感染，预防自身免疫病的发生及抗衰老等作用。
his paper reports
that the effect of AMB on the cytokines in aging mice and elderly
sub-jects. The results indicated that the cytokines of elderly
organism were markedly lower thanthose of control group,but after
treatment with AMB, the immune function vvas significantlyincreased.
The IL-2 . TNF and IFN-γ in the culture fluid of spleen cells from
aging mice wasdetermined with bioassavs method and the sIL-2R was
examined with ELISA. The resultsshowed that the levels of IL-2、TNF
and IFN-γ were more higher than those of control group inafter
treatment of AMB, but the level of sIL-2R was decreased
significantly. Thus the authorbelived that AMB may play a regulatory
role on immunological function and against infecti on,tumor,
autoimmune disease.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1995年第3期167-169,共3页
Chinese Journal of Immunology
