摘要
本文对心血管病人用药情况进行了调查并集中监测药物不良反应，探寻不良反应的危险因素。监测期１４个月，在７４５人中发生２２４例不良反应，发生率２３．２％，Ａ型１９９例，Ｂ型２５例，轻度：中度：重度＝７０：１３２：２２。主要累及心血管系统（３７．９％）、中枢神经系统（２４．６％）和消化系统（１５．６％）。发生不良反应者的用药种数和住院时间显著超过没有不良反应者（女性：１２．１±６．０ｖｓ１０．２±４．６种，Ｐ＜０．０５；４７．９±３９．１ｖｓ３０．９±１９．２ｄ，Ｐ＜０．０１。男性：１４．２±６．９ｖｓ１１．４±５．３种，Ｐ＜０．０１；６７．９±５８．８ｖｓ４７．３±５４．２ｄ，Ｐ＜０．０１）。抗心律失常药和地高辛是主要致不良反应药物。用药种类多、住院时间长是不良反应发生的主要危险因素。
The present investigation is to evaluate drug prescription,to carry out an intensive hospital survey of adverse drug reactions(ADRs)among patients with cardiovascular diseases, and to search for the risk factors of ADRs.Of 745 in-patients, 173(23.2%)had 224 ADRs in 14-month of surveillance.199 ADRs were classified as type A and 25 as type B. Mild:moderate:severe=70:132:22.The major systems involved were cardiovascular(37. 9%), central nervous(24.6%)and gastrointestinal systems(15.6%).Patients with ADRs were exposed to more drugs and had longer hospitalstay than those without ADRs(sex=f 12.1±6.0 vs 10.2±4.6,P<0.05;47.9±39.1 vs 30.9±19.2.P<0,01; sex=m,14. 2±6.9vs 11.4±5,3,P<0,01, 67.9±58.8 vs 47.3±54.2,P<0.01),The most commonly involved drugs are antiarrhythmics and digoxin. Polypharmacy and long hospital stay are major risk factors of ADRs.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1995年第4期234-240,共7页
The Chinese Journal of Clinical Pharmacology
关键词
心血管疾病
医院内监测
药物副作用
cardiology departmen
hospital surveillance
adverse drug reaction
