摘要
本文研究了８名健康志愿者单剂口服索他洛尔１６０ｍｇ后药代动力学，用高效液相色谱法测定血清和尿样中索他洛尔浓度，结果表明：药代动力学呈二室模型，Ｔｌａｇ０．３３±０．１０ｈ，Ｔｍａｘ３．３８±０．６９ｈ，Ｃｍａｘ１．６２±０．３２ｍｇ／ｌ，ＡＵＣ１６．２±３．１ｍｇ·ｈ￣（－１）·Ｌ￣（－１），Ｔ＿（１／２）β１４．２±５．０ｈ，Ｖｄ３．６４±１．３５ｌ／ｋｇ，ＣＬ１６９．２±２８．８ｍｌ／ｍｉｎ，我国索他洛尔药代动力学与西方人近似，具有生物利用度较高、表观分布容积较大以及半衰期较长的特点，而且无性别之间的显著差异．
The pharmacokinetics of sotalol were studied in 8 Chinese healthy volunteers after a single oral administration of 160mg.The serum and urine concentration of sotalol were measured by HPLC.The results demonstrated that pharmacokinetics of sotalol was a fit to fit two-compartment model and the mean Tlag was0.33±0.10h.Tmax3.38±0.69h,Cmax 1.62±0.32mg/l,AUC 16.2±3.1mg·h-1·L-1,T1/2β14.2±5.0h,Vd 3.64±1.35 l/kg and CL 169.2±28.8 ml/min.These results are similar to the pharmacokinetics in the Caucasians.There was no significant difference between male and female in the pharmacokinetics of sotalol.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1995年第3期141-145,共5页
The Chinese Journal of Clinical Pharmacology
