摘要
为观察双氯芬酸钠凝胶外用治疗类风湿关节炎（ＲＡ）的疗效和安全性，我们对其与阳性对照药吲哚美辛擦剂治疗１２２例ＲＡ进行了随机、单盲，平行性和多中心的临床验证。结果表明：双氯芬酸钠凝胶治疗６７例ＲＡ的总有效率为７１．６４％，不良反应发生率为１０．４４％；吲哚美辛擦剂治疗５５例ＲＡ的总有效率为６１．８２％不良反应发生率为３６．６％。提示两药的疗效相近，但前者的不良反应发生率明显低于后者。
To study the efficacy and safety of diclofenac sodium gel (DSG) in patients with rheumatoid arthritis (RA),radomized,controlled,single-blind clinical trial of DSG versus indomathacin embrocation (IE) were studied. The results indicated that the total efficacy rates of DSG and IE were 71.64% and 61.82% respectively after two weeks'treatment.The incidences of adverse effects associated with DSG and IE were 10.44% and 36.36%.These results suggest that DSG had a similar efficacy with IE in the treatment of patients with RA, but its adverse effects were significantly lower than that of IE.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1995年第1期11-15,共5页
The Chinese Journal of Clinical Pharmacology
关键词
双氯芬酸钠
凝胶
吲哚美辛擦剂
类风湿性关节炎
diclofenac sodium gel
indomathacin embrocation
rheumatoid arthritis
clinical trial
