摘要
以５×１０３ｃｆｕ／鼠的新型隐球菌给小鼠脑室感染（ｉｃ）１ｈ后，分别口服氟康唑（Ｆｌｕ）５和１０ｍｇ／（ｋｇ·ｄ）或酮康唑（Ｋｅｔ）５０和１００ｍｇ／（ｋｇ·ｄ），ｂｉｄ×９ｄ。对ｉｃ小鼠连续观察４０天的存活率和平均存活时间，Ｆｕｌ分别为５０％～７０％和８～１５天，Ｋｅｔ是３０％～４０％和５～９天。由小鼠侧尾静脉注射１０６ｃｆｕ／鼠新型隐球菌３天后产生的全身感染，分别给小鼠口服Ｆｌｕ２．５～１０ｍｇ／（ｋｇ·ｄ）或Ｋｅｔ２５～１００ｍｇ／（ｋｇ·ｄ），ｂｉｄ×９ｄ。感染２４、２８和３２天的ＰＤ５０Ｆｌｕ是２．７、３．５和６．７ｍｇ／ｋｇ，Ｋｅｔ为２８．４、７０．４和８３ｍｇ／ｋｇ；Ｆｌｕ和Ｋｅｔ的平均存活时间分别是２３～３４天和２０～３１天。在上述两种实验模型中分离脑和肺做细菌培养，Ｆｌｕ均与对照和５０ｍｇ／（ｋｇ·ｄ）的Ｋｅｔ比较，对ｉｃ１０天及静脉注射感染１３天的小鼠，口服５和１０ｍｇ／（ｋｇ·ｄ）或２．５～１０ｍｇ／（ｋｇ·ｄ）Ｆｌｕ均显著抑制新型隐球菌生长。
ne hour after intracerebrally (ic) infecting with 5 × 103 cfu/mouse
ofCryptococcus neoformans. animals were orally administered 5 and 10mg/( kg . d )
offluconazole and 5.0 and 100 mg/(kg . d) of ketoconazole, bid × 9d, respectively. In a period
of 40 days, the survival rate and mean survival time of fluconazole and ketoconazole were50%
to 70%, 8 to 15 days; and 30% to 40%, 5 to 9 days respectively.A systemic infection study was
performed by injection into the lateral tail vein of 106cfu/mouse of C neoformans , and 3 days
after, animals were orally administered 2. 5 to10mg/(kg . d ) of fluconazole and 25 to
100mg/(kg. d) of ketoconazole bid × 9d,respectively After 24. 28 and 32 days, the PD50 of
fluconazole and ketoconazloe are 2. 7 ,3. 5 and 6. 7; and 28, 4, 70. 4 and 83mg/ kg ; and the
mean survival time of fluconazole andketoconazole are 23 to 34 and 20 to 31 days
respectively.When compared with the contril and ketoconazole of 50mg/(kg . d ) dosage
groups. theanimals after 10 days of intracercbrally 13 days intravenously as well as the
closage regimenof 5 and 10 or 2. 5 and 10mg (kg·d ) of fluconazole, the bacteriological
studies revealed thatthe tes t or ganisms we re s inificantly inhibited.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1995年第3期212-216,共5页
Chinese Journal of Antibiotics
关键词
氟康唑
酮康唑
隐球菌
脑膜炎
全身性
隐球菌病
Fluconazole
Ketoconazole
Cryptococal meningitis Systemic cr yptococcosis
