摘要
ｓｕｌｐｅｒａｚｏｎｅ与其它抗生素对β－内酰胺酶的稳定性比较结果表明：ｓｕｌｐｅａｚｏｎｅ对１２个标准酶中的１１个酶均高度稳定，对ＴＦＭ－１、ＴＥＭ－２和ＳＨＶ－１的稳定性较头孢酮显著增强，与头孢噻肟相同。对１４个临床分离高度耐药菌所产生的β－内酰胺酶，ｓｕｌｐｅｒａｚｏｎｅ的酶稳定性也较头孢酮显著加强，其中１２个酶对ｓｕｌｐｅｒａｚｏｎｅ的相对水解率较头孢酮降低２．２～８０．２倍。对６个超广谱酶，ｓｕｌｐｅｒａｚｏｎｅ具有较好的酶稳定性，对肺炎克雷伯氏菌Ｎｏ，１０９１、４４７、８７７和异型枸橼酸杆菌Ｎｏ．８８７的酶稳定性好于头孢酮和头孢噻肟，与头孢他啶和氨曲南接近。
β- lactamase stability of sulperazone was compared with those ofcefoperazone,cefotaxime,ceftazidime and aztreonam。Results showed that sulperazone wasstable to 11 of 12 standard-β- lactamases,its stabilities to TEM-1,TEM-2 and SHV-1,arethe same as cefotaxime and were higer than that of cefoperazone。Sulperazone was more stable to l2 β-lactamases produced by clinical resistant isolatesthan cefoperazone,the relative hydrolysis rates of cefoperazone were 2.2～80.2 times higherthan those of sulperazone。The stabilities of sulperazone to 4 extend-broad-β-lactamses(K.pneumoniae No. 1091,447,877 and C,diversus No. 887)were higher than those ofcefoperazone and cefotaxime。
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1995年第3期173-177,共5页
Chinese Journal of Antibiotics
基金
国家自然科学基金
