摘要
过去的十几年是遗传学,尤其是分子遗传学发展的鼎盛时期,这种发展,极大地推动了生物技术产业,尤其是单基因产品产业化的发展。然而,对抗生素这种特殊的生物产品而言,因为它是由一套成簇排列的基因协同作用所产生的,只有合成出来的终产物才具有生物活性,所以相对来说,利用分子遗传学的高新技术来进行抗生素效价和品种的遗传工程改良就不如单基因产品那样简单易行。不过,对一系列抗生素生物合成基因簇的克隆及对这类生物合成途径及其遗传调控机理的了解,已为我们提供了许多有益的信息,使我们能把经典的和现代的方法学结合起来,通过对抗生素产生菌的遗传操作来大大提高菌种的产率,或“说服”微生物产生它原本不产生的抗生素。本文根据现有知识来讨论和阐述这个诱人领域的发展前景。
An outburst of studies has been seen in the area of genetics and especially molecular genetics over the past decade. Many developments greatly stimulated a dramatic expansion of the biotechnology industry particularly in the direction of the products of single genes. Antibiotics, a class of complex products usually resulted from the concerted action of a cluster of genes, are more difficult to manipulate in terms of yield increase and creation of new products. However, the sucessful cloning of a number of antibiotic biosynthetic gene clusters and understanding of the genetic control of antibiotic production in more and more depth are now providing useful information that should allow the imaginative application of a combination of traditional and modern techology for the yield improvement and creation of antibiotics using Streptomyces species. Here we will discuss the rapid development in this tempting and prosperous field.
出处
《中国科学基金》
CSCD
1995年第1期2-8,共7页
Bulletin of National Natural Science Foundation of China
关键词
链霉菌
抗生素
遗传工程
产率
Streptomyces, Antibiotic, Genetic engineering
