摘要
本文观察８ｗｋ龄Ｃ５７ＢＬ／６小鼠感染日本血吸虫尾蚴后不同时期脾细胞经ＳＥＡ或ＣｏｎＡ刺激，体外诱生的ＩＬ－２和ＩＦＮ－γ活性变化。结果表明两种细胞因子活性均在感染后第４－６ｗｋ开始上升，第６—８ｗｋ达高峰，第１２—１４ｗｋ恢复至感染前水平。ＩＦＮ－γ高峰时间略先于ＩＬ－２。非特异性刺激原诱生组和特异性刺激原诱生组各阶段细胞因子活性动态基本一致，前组活性高于后组。提示ＩＦＮ－γ与ＩＬ－２活性与血吸虫卵肉芽肿的诱导、成熟与维持有密切关系。
The capacity of mitogen Con A and SEA stimulated spleen cells to produce cytokines IFN γ and IL 2 was studied in S.japonicum infected mice every two weeks from o to 14 wk after infection. The results showed that the levels of these two cytokines began to rise at the 4th wk after infection and reached a peak level at 6 8 wk, then declined to the levels similar to those pre infection at 12 14 wk after infection. The IFN γ level reached the peak earlier than the IL 2 level. The dynamics of cytokine level in both mitogen and antigen stimulated group was similar. The results suggest that IL 2 and IFN γ might be the essential cytokines involved in egg granuloma formation in schistosomiasis japonica.
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
1995年第1期35-38,共4页
Chinese Journal of Parasitology and Parasitic Diseases
