摘要
本文观察了盐藻提取物（ＥＤＳ）对尘肺病人抗氧化和细胞免疫功能的影响。尘肺病人口服ＥＤＳ胶丸，每次１５ｍｇ，每日两次，疗程１个月。结果显示，血清ＢＣ和ＶＡ含量明显升高的同时，血脂质过氧化物（ＬＰＯ）含量骤降（Ｐ＜０．０１），血超氧化物歧化酶（ＳＯＤ）和谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性明显升高（Ｐ＜０．０１）；细胞免疫功能也有所改善，表现为肿瘤坏死因子（ＴＮＦ）活性升高（Ｐ＜０．０１）和淋巴细胞转化率（ＬＣＴ）增加（Ｐ＜０．０５）。本研究结果提示，ＥＤＳ是一种具有抗氧化、提高免疫功能安全有效的药物，值得在尘肺防治中进一步研究。
he effect of EDS on
antioxidation and cel-lular immune function in patients with pneumo-coniosis who took EDS
capsules(15mg each,twice adav)for 30 days was observed in thestudy. The results showed that
while serum be-ta-carotene and vitamin A levels increased,blood lipid peroxides(LPO) content
markedlydecreased(P<0.01),and the activities of su-peroxide dismutase(SOD)and glutathione
per-oxidase(GSH-Px) were significantly increased(P<0.01)than those before administration
ofEDS.Cellular immune functions,such as the ac-tivity of tumor necrosis factor(TNF)and
lym-phocyte transformation rate(LCTR) improved,that was TNF activity increased(P<0.01
)andLCTR raised(P<0.05 ).It was suggested thatwas effective in improving antioxidation
andimmunologic functions of pneumoconiosis pa-tients and was safe at the dose tested.and
thatit is worthy to do further study on the action ofthis drug in prevention and treatment of
pneu-moconiosis.
出处
《中国工业医学杂志》
CAS
1995年第5期260-262,共3页
Chinese Journal of Industrial Medicine
关键词
尘肺
盐藻提取物
抗氧化作用
细胞免疫功能
药理
pneumoconiosis,beta-carotene(BC),extracts of dunaliella
salina(EDS),an-tioxidation,immunologic function
