摘要
对静脉注射油酸引起急性肺损伤的（ＡＬＩ）大鼠，在注射后不同时间收集支气管肺泡灌洗液（ＢＡＬＦ）和血清进行分析，发现其ＢＡＬＦ中乳酸脱氢酶（ＬＤＨ）、碱性磷酸酶（ＡＬＰ）、总胆固醇（ＴＣ）和磷脂（ＰＬ）均有不同程度增加，注射后０．５小时ＬＤＨ即增高达对照组的６．７倍（Ｐ＜０．００１）。血清中ＬＤＨ，ＡＬＰ，ＴＣ及ＰＬ均有异常改变，其中注射后０．５小时血清ＬＤＨ即高达对照组的２倍（Ｐ＜０．０１）。实验组ＢＡＬＦ及血清中甘油三酯（ＴＧ）均比对照组有所降低。实验提示，ＢＡＬＦ和血清中ＬＤＨ升高伴脂类异常，有可能是早期诊断急性肺损伤较特异的组合指标。
cute lung injury(ALI)of rats was
in─duced by injection of oleic acid. After injec─tion, the levels of lactate dehydrogenase(LDH),
alkaline phosphatase(ALP), total cholesterol(TC), triglyceride(TG)and phospholipid(PL)in
bronchoalveolar lavage fluid (BALF)and serum were periodically quantified. Theresults showed
that the levels of LDH,ALPTC and PL in BALF were increased, thelevel of LDH in BALF even
increased to 6.7─folds of the control at 0.5 hour after injection(P<0.001). Serum LDH level
increased to 2─folds of control at 0.5 hour after injection(P<0.01). TG in BALF and serum of rats
withALI were decreased compared with the con─trol. It was suggested that the increase of
LDHwith the abnormalities of lipids(TC, TG andPL)in BALF and serum may be served as aearly
specific combined parameter for thediagnosis of ALI.
出处
《中国工业医学杂志》
CAS
1995年第4期196-199,共4页
Chinese Journal of Industrial Medicine
