摘要
用微生物方法测定了同一药厂2个批号的红霉素肠溶片的体外溶出和8名健康志愿者口服的体内吸收,结果表明国内文献方法和美国药典方法测定的溶出度无统计学差异;两种肠溶片体外溶出度有明显差异,体外溶出度大的肠溶片其体内吸收和生物利用度也大。提示体外溶出试验应作为红霉素肠溶片剂的质控指标。
The dissolution of erythromycin enteric coated tablets of twobatches produced by the same manufacturer and their absorption in 8 volunteerswere determined by microbial assay.The results of dissolution determined by theinternal literature and USP methods were similar (p>0.05). The tablets withhigher dissolution had better absorption and bioavailability. So the dissolutiontest of erythromycin enteric-coated tablets should be taken for the quality control.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1989年第11期504-506,共3页
Chinese Journal of Pharmaceuticals
关键词
红霉素
肠溶片
体外溶出
体内吸收
erythromycin, enteric-coated tablet, dissolution, absorption,bioavailability, pharmacokinetics
