摘要
本实验观察丙谷胺(Proglumide,PGM)对大鼠,狗和T管引流病人的胆汁分泌量和成分的影响,发现静脉注射或口服PGM后胆汁的分泌量明显增加,人和狗胆汁中的电解质、胆固醇、胆红素、总胆酸、卵磷脂及蛋白质的排出量均较给药前增加或明显增加。实验结果提示PGM具有明显的利胆效应。
Proglumide(PGM) is a CCK/gastrin receptor antagonist. The purpose of this study was to observe the effect of PGM on bile flow and the outputs of bile contents in humans and animals. Methods:1) In patients who had undergone cholecystectomy, bile was collected through T tubes during fasting at 15 min intervals before (control) and after PGM 1.2 ingestion. Drinking water test was done under the same conditions. 2) Dogs and rats were fasted overnight, and the common bile duct was cannulated for bile collection. PGM was given intravenously in bolus. Bile flow, electrolytes, cholesterol, bi-lirubin, total bile acid, protein and lecithin (content) were measured in humans and dogs. The values were expressed as value per 15 min and compared with control using the Student's t-test. The results show: bile flow, outputs of HCO3-, K+ , Na+, CI-, Ca2+, cholesterol, bilirubin, total bile acid and protein levels all increased remarkably after PGM administration. In rats, the bile flow increased in a dose response manner between PGM dosages of 100 , 200,400mg/kg (r=0.795, P<0.001 at 15-30 min). We conclude that PGM has a choleretic effect in human as well as in animals of different species.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1989年第4期278-282,共5页
Acta Academiae Medicinae Sinicae
关键词
丙谷胺
利胆效应
胆汁
proglumide (PGM) cholecystokinin (CCK) antagonist choleretic effect
