摘要
氮酮为药物经皮吸收的高效,低毒的助渗剂。使用的最佳浓度可根据药物及其剂型经实验确定,一般用量仅需2～10%,浓度过大可能效果相反。其作用机制尚未完全清楚,实验初步征明,氮酮能促进大多数亲水性药物对角质层的穿透,缩短药物在角质层的滞留时间。氮酮的合成和应用将推动外用剂型和 TTS 的迅速发展。
Azone is a highly effective and low poisonous penetration enhancer in percutaneous absorption of drugs.The most suitable concentration of azone can be determined by experiments on drugs and their forms.Usually,the quantity used is about 2-10%.If the concentration is too high,it is possible to produce theopposite effects.The mechanism of azone is obscure,but experiments have proved that it can promotemost hydrophilic drugs passing through the stratum corneum and reduce their detaining time.The synthesisand application of azone will promote the rapid development of its externally used preparation and TTS.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1989年第1期19-21,共3页
Chinese Pharmaceutical Journal
关键词
氮酮
助渗剂
药物
皮肤
azone
percutaneous absorption of drug
accelerant
promotion
