摘要
测定了醋氨已酸锌（ＺＡＣ）在大鼠体内的药代动力学。结果表明：大鼠ｐｏＺＡＣ吸收迅速，给药后１．５ｈ即可达峰，其后稍快下降。３个剂量组的吸收峰时及半衰期基本一致，Ｔ１／２约在１．５ｈ，峰浓度、ＡＵＣ及ＣＬ／Ｆ呈剂量依赖关系。ＺＡＣ在大鼠的药代动力学模型为一室模型。组织分布的实验结果表明：服药２ｈ后药物可广泛分布于各组织中，主要集中在胃、肠；肾、肝、血浆及肺次之；心、脾、脑较低；肌肉、子宫未检出。６ｈ后胃中含锌量稍降，肺中含量变化不大，其它组织的药物浓度普遍明显下降，表明该药在组织中不易蓄积。ＺＡＣｐｏ后主要经粪排出，尿及胆汁仅排出少量药物。
Zinc
acexamate(ZAC)is a new antiulcer drug.This paper reports the
pharma-cokinetics of ZAC in rats after single oral administration.The
concentrations in biological sampleswere detected by
spectrophotometry.This study shows that the concentration-time curve
of ZAC inblood conformed to a single-compartment open model after
250,500 and 750 ng·kg-1 ig.ZACabsorption was fast and the peak
plasma level appeared in 1.5h.The Cmax,AUC and CL/F wereshown to be
dose dependent.Two hours after oral administration of ZAC to nomal
rats,the highestlevel of ZAC was present in the gastrointestinal
tract,while appreciable ZAC was present in thekidney,liver,plasma and
lung.The level of ZAC in heart,spleen and brain Was lower,no drug
wasdetected in muscles and uterus.Six hours after oral
administration,the drug concentration in varioustissues decreased
rapidly,but that of the gastrointestinal decreased very slowly.Feces
excretion was animportent route of excretion.ZAC excretion was about
11.7% of the administered dosage in feceswithin 48 h period,and the
excreted amount from urine and bile was very small.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第1期17-20,共4页
Acta Pharmaceutica Sinica
