摘要
卡普地尔与山莨菪碱合用对结扎大鼠冠脉左室支造成心肌缺血再灌注损伤的保护作用。两药同时合用可降低缺血再灌性心律失常发生率；明显提高复灌后心肌超氧物歧化酶活性及显著减轻心肌超微结构损伤。表明两药合用有协同作用，较单用苄普地尔或山莨菪碱疗效好。
The effects of bepridil(Bep
)in combination with anisodamine(Ani )on myocardial ischemia and
reperfusion injury induced by ligating the left coronary artery were
studied in rats Administration of a combination of Bep and Ani was
found to decrease the incidence of arrhythmia induced by myocardial
ischemia and reperfusion,increase the myocardial superoxide
dismutase(SOD)activities and reduce the myocardial ultrastructural
injury in rats.The effect of combination of Bep and Ani was shown to
be better than either Bep or Ani alone.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第1期1-5,共5页
Acta Pharmaceutica Sinica
关键词
苄普地尔
山莨菪碱
心肌
再灌注损伤
歧化酶
Bepridil
Anisodamine
Myocardial reperfusion injury
Superoxide
dismutase
