摘要
用离体犬脑血管（基底动脉）环标本，观察γ－氨基丁酸（ＧＡＢＡ）对几种不同激动剂所致最大收缩反应的舒张作用。苯福林（ＰＥ）１０μｍｏｌ·Ｌ－１，５－羟色胺（５－ＨＴ）１０μｍｏｌ·Ｌ－１以及２５ｍｍｏｌ·Ｌ－１的ＫＣｌ均可使脑血管静息张力增加，ＧＡＢＡ５０μｍｏｌ·Ｌ－１对以上几种激动剂所致的收缩反应均有舒张作用。对较高浓度的ＫＣＩ（４５ｍｍｏｌ·Ｌ－１）所致的收缩无影响，但对由冷刺激（未预热的营养液，２８℃）引起的收缩反应有明显的舒张作用。
The present experiments were designed to
investigate the effects of γ-aminobutyricacid(GABA) on isolated dog
cerebral arteries(basilar arter). on addition of agonists
phenylephrine10μmol·L-1,5-HT 10μmol·L-1, or KCl 25 mmol·L-1, the
isometric tension of the contrac-tion increased 0,51±0.18g,0.33±
0.12 g and 0.57±0.16g. After GABA at 50μmol·L-1,the contraction
was shown to decrease 0.27±0.15g,0.19±0.07g and 0.17±
0.06g,themaximal relaxation were 45.49%±26.4%, 58.60%±12.96%and 27.
75%±15.78%,respectively. But it showed no effect on the contraction
induced by high concentration of KCl (45mmol·L-1).GABA also showed a
potent relaxation on the contraction induced by cold Krebssolution(T
28±0.5℃). The finding suggest that GABA can inhibit the muscle tone
induced byvarious agonists and cooling in isolated dog basilar
artery.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第8期573-576,共4页
Acta Pharmaceutica Sinica
基金
国家自然科学基金
关键词
脑血管
R-氨基丁酸
犬
收缩反应
舒张作用
Isolated cerebral vessels ring
Basilar artery
Gamma-aminobutyric acid
