摘要
目的：比较卡铂（Ｃａｒ）与顺铂（Ｃｉｓ）联合化学疗法（化疗）对晚期恶性肿瘤的疗效。方法：以Ｃａｒ为主的联合化疗组１２０例（男性１０１例，女性１９例，中位年龄５５ａ）；以Ｃｉｓ为主的联合化疗组１２２例（男性１０５例，女性１７例，中位年龄５４ａ）。结果：Ｃａｒ组缓解率（５４．２％）高于Ｃｉｓ组（４５．１％）（Ｐ＜０．０５），特别对小细胞肺癌、肺鳞癌、卵巢癌和食管癌，Ｃａｒ对胃肠道和肾毒性较Ｃｉｓ为轻，但对骨髓毒性显著为重（Ｐ＜０．０１）。结论：Ｃａｒ可作为上述恶性肿瘤联合化疗的一线药物。
AIM: The efficacies of carboplatin-combined chemotherapy were compared with those of cisplatin-combined chemotherapy in the patients with advanced malignant tumors. METHODS: Two hundred and forty-two patients were divided randomly into two groups. the carboplatin(Car) group(M 101, F 19, median age 55 a) and the cisplatin(Cis) group(M 105, F 17, median age 54 a). RESULTS: The results showed that the remission rate(54.2%) in Car group was higher than that(45.1%) in Cis group. The Car had better efficacy than Cis especially in treating small cell lung cancer, squamous cell lung cancer, ovary cancer and esophageal cancer. The toxicity of Car was milder for kidney and gastro-intestinal tract but more serious for bone marrow than that of Cis. CONCLUSION: Car could be a drug of good chioce in the treatment of malignant tumors.
出处
《新药与临床》
CSCD
北大核心
1995年第5期274-277,共4页
关键词
肿瘤
抗肿瘤药
卡铂
顺铂
联合抗肿瘤药
neoplasms
carboplatin
cisplatin
combined antineoplastic agents
